The Effect of Azithromycin Plus Zinc Sulfate on ACE2 Expression through I?B? of Human Respiratory Cells in SARS-CoV-2: In Vitro Study

Large-scale efforts have been persistently undertaken for medical prophylaxis and treatment of COVID-19 disasters worldwide. A variety novel viral spike protein-targeted vaccines extensively distributed global inoculation based on accelerated approval. With concerns emerging protein mutations, we revisited the early but inconclusive clinical interest in repurposed combination azithromycin (AZT) zinc supplements with safety advantages. The aim this study is to provide vitro proof concept I?B? associated rapid synergistic suppression angiotensin-converting enzymes 2 (ACE2) following treatments AZT plus sulfate two human airway cells ACE2 expression, Calu-3 H322M, representative upper lower origin respectively. Clinical timing combined indicated key cellular entry molecule, ACE2, SARS-CoV-2.